What is the problem?
NMDA receptors are like gatekeepers in the brain that help control memory, learning, and nerve cell communication. They play a big part in the development of diseases like ischemic stroke (a type of stroke caused by blocked blood flow to the brain) and Alzheimer's disease.
Scientists have tried to develop drugs that block these receptors to treat Stroke, but so far, none have proven effective enough to be used as treatments.
For Alzheimer's disease, NMDA receptor blockers are mainly used to manage symptoms rather than cure the condition with memory and daily activities, they can help some patients, but these drugs don't stop or slow the disease's progression. Their benefits can vary depending on the individual, and they may be more effective for people in the early stages of Alzheimer's disease. However, the improvement they provide is generally mild.
Stroke & Alzheimer's Disease
Stroke is the second most common cause of death and the third common reason for disability worldwide. Whereas, more than 55 million people have dementia worldwide and this number is expected to rise to 78 million in 2030 and 139 million in 2050. Alzheimer disease is the most common form of dementia and may contribute to 60-70% of cases.
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Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, et al. Global and regional burden of stroke during 1990-2010: findings from the global burden of disease study 2010. Lancet. 2014;383(9913):245–254.
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In these conditions, NMDA receptors, which help brain cells to communicate, are extremely involved. They play a key role in the development of both stroke (caused by blood flow issues in the brain) and Alzheimer’s disease (a memory loss disease). So, checking for changes in the enzyme that control NMDA receptors might help doctors to detect these brain conditions early on.
Who we are
A startup company creating an affordable and easy-to-use technology that can predict the early signs of brain-related diseases like Stroke and Alzheimer’s disease without the need for invasive procedures. This tool aims to help detect these conditions early, making it easier for people to take preventive action before they fully develop.
How it works?
Detecting the specific enzyme that regulates NMDA receptors in blood or saliva could be an easy way to monitor brain health early on. This enzyme serves as an early warning sign for brain-related diseases, such as stroke and Alzheimer’s disease.
The technology uses a special method to detect a substance called D-serine, which is converted by an enzyme linked to the health of NMDA receptors in the brain.
What is the technology?
This technology is a wearable device that lets you check your brain health easily and affordably.
It includes a saliva test strip that you place in your mouth—no needles or blood tests needed. The test strip has special electronic ink that can analyse your saliva to help predict your risk of future brain-related conditions, like stroke and Alzheimer’s disease.
This tool is designed to be low-cost, convenient, and can be used at home in future.
